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Technologies - Biology and Medicine
A novel approach to isolate the Androgenic sex hormone (AH) from the crustacean freshwater prawn and marine shrimp using in vitro glandular secretion of the AH from AH-producing Androgenic glands. |
A novel optical-fiber sensor configuration has been developed for use in parallel bioreactor arrays and other potential applications. A major advantage of this configuration (as opposed to the commonly applied backscattering configuration) is that it minimizes or eliminates the effect... |
Two innovative sensor-protein platforms have been developed by UH researchers. These sensors are designed for highly sensitive fluorescence resonance energy transfer (FRET)-based molecular assays. Both sensors are suited for homogeneous assays, with one of the sensors designed for... |
The Flightless-I Protein was originally identified in the vinegar fly Drosophila but it is conserved in most multicellular organisms, including humans. Studies have shown that mutations in this gene result either in abnormal muscle function or in arrested development and embryonic lethality. |
Pre-term birth is a serious medical problem in the U.S. with almost half a million babies born prematurely each year. In spite of all recent medical advancements, the premature birth rate continues to climb and the reasons remain unknown. |
Examination of mitotic chromosomes is essential for cytogenetic research, in particular for the chromosomal mapping of the genes responsible for some genetic disorders and cancers linked with the chromosomal alterations. |
This new microtubule-stabilizing agent is an effective cytotoxin against many cancer cells in vitro. Bioassay-directed purification of the crude lipophilic extract yielded a steroid with paclitaxel-like microtubule-stabilizing activity. |
The technology covers the construct consisting of the baculovirus polyhedron promoter, the yeast flg5 leader sequence, and the p42 MSP1 sequence with the transmembrane domain deleted cloned at the University of Hawaii from the Uganda-Palo Alto isolate of P. falciparum. |
The invention consists of two parts which both contribute to an enhanced feasibility of commercial production of this potential malaria vaccine: (1) optimization of the MSP1.42 gene construct for enhanced levels of production in the... |
This technology describes a method of producing transgenic tobacco plants that synthesize the complete P. falciparum MSP1 p42 polypeptide. This structure of the plant MSP1 p42 recombinant polypeptide appears to be similar to that obtained from P. falciparum as well as... |
Malaria is a tropical disease that annually infects 200 million people in developing countries, with an estimated 2 -2.5 million people, mostly children, that die of this disease. Globally, over one billion people are at risk of contracting malaria infections. |
Two genes which are unique to serotype cluster IIB (4b - 4d - 4e) have been characterized for Listeria monocytogenes. Serotype 4b is known to be the primary pathogenic species causing listeriosis. The serotype-specific region has been sequenced in its entirety from both strands. |
Two pairs of DNA primers have been designed to be used in the Polymerase Chain Reaction System (PCR) to consecutively detect both Salmonella and Shigella. The method used to detect the bacteria involves isolating and purifying nucleic acids... |
The DZ-1 monoclonal antibody detects specific antigen for the leprosy bacillus, Mycobacterium leprae. The recognized antigen is Phenolicglycolipid-I (PG-I). The monoclonal antibody reacts with the innermost sugar (0-3-methylrhamnose) of the trisaccharide antigenic component of the PG-I. |
The design includes piezoelectric bimorph bender elements that scan the aperture in the confocal image plane to create a compact, relatively inexpensive, rugged confocal microscope which can be remotely deployed on a fiber optic cable and miniaturized for in situ analysis. |
Medical diagnostics using chemical sensing of antibody, antigens, DNA fragments and other biochemicals are addressed using semiconductor sensors and supportive biochemical processes. This successful marriage of semiconductor sensors and biochemistry..... |
We discovered that an essential oil and its constitutes are very toxic to pest tephritid fruit flies including Ceratitis capitata (Wiedemann) (Mediterranean fly), Bactrocera dorsalis (Hendel) (oriental fly) and B. cucurbitae (Cocquillett) (melon fly). Pest tephritid fruit flies directly damage... |
This invention relates to use the reactions between cationic metals and hydrides to generate free radicals and undergo subsequent oxidation to destroy organic chemicals and kill human cancer cells. |
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